Research Guide
MOTS-C
The mitochondrial-derived research compound for metabolic health, exercise capacity and longevity research.
Overview
MOTS-C is a 16-amino-acid research compound encoded within the mitochondrial 12S rRNA — one of a handful of known mitochondrial-derived research compounds. Heavily studied in metabolic health, exercise performance and longevity literature.
Mechanism of action
MOTS-C activates AMPK, the cell's master energy sensor, increasing glucose uptake and fatty acid oxidation. Animal studies show improved insulin sensitivity, increased exercise capacity, and reduced age-related metabolic decline.
Reference range (research literature)
Common research protocols use 5–10mg per week, split into 2–3 subcutaneous injections.
Half-life
Approximately 3 hours systemically.
Reconstitution
Reconstitute the 10mg vial with 2ml bacteriostatic water. Each 0.2ml = 1mg. Refrigerate and use within 30 days.
Comparisons
vs Metformin
Both activate AMPK; MOTS-C does so via a distinct mitochondrial mechanism and shows broader exercise effects.
Commonly researched stacks
- Tesamorelin (GH axis)
- BPC-157 / TB-500 (recovery)
Frequently asked
Best time to dose?
Research often uses post-exercise or morning administration.
Is MOTS-C naturally produced?
Yes — it is endogenously encoded in mitochondrial DNA, but levels decline with age.
Disclaimer: Information on this page is for research and educational use only. Research compounds sold by AUSPEPS are not approved for human consumption and are intended exclusively for laboratory research.